Coronary artery disease

The ARC-2 initiative (2018) updated the widely used ARC-1 pragmatic consensus definitions for coronary device trials (2007) to incorporate experience gained with the initial definitions, interim recommendations from professional societies, and the expansion of clinical trials to include more complex patient/lesion subsets and novel devices. Coronary research definitions continue to evolve and the ARC-3 initiative is ongoing.

Note: paragraph partially extracted from ARC-2, available through the link below.

ARC Publications

Academic Research Consortium (ARC-1) - Coronary

• Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions. Circulation 2007; 115:
2344-2351
https://pubmed.ncbi.nlm.nih.gov/17470709/

Academic Research Consortium 2 (ARC-2) – Coronary

• Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2
Consensus Document (ARC-2, 2018). Eur Heart J. 2018 Jun 14;39(23):2192-2207
https://pubmed.ncbi.nlm.nih.gov/29897428/

• Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2 Consensus Document (ARC-2, 2018). Circulation. 2018 Jun 12;137(24):2635-2650.
https://pubmed.ncbi.nlm.nih.gov/29891620/

Independence of clinical events committees: A consensus statement from clinical research organizations.

Reference: Am Heart J. 2022 Jun; 248:120-129.

Clinical events classification (CEC) in clinical trials: Report on the current landscape and future directions - proceedings from the CEC Summit 2018.

Reference: Am Heart J. 2022 Apr;246:93-104.

Defining device success for percutaneous coronary intervention trials: a position statement from the European Association of Percutaneous Cardiovascular Interventions of the European Society of Cardiology.

Reference: EuroIntervention. 2020 Jan 17;15(13):1190-1198.

Critical Appraisal of Contemporary Clinical Endpoint Definitions in Coronary Intervention Trials: A Guidance Document.

Reference: JACC Cardiovasc Interv. 2019 May 13;12(9):805-819.
https://pubmed.ncbi.nlm.nih.gov/22017945/

Defining Staged Procedures for Percutaneous Coronary Intervention Trials: A Guidance Document.

Reference: JACC Cardiovasc Interv. 2018 May 14;11(9):823-832.

Detecting Periprocedural Myocardial Infarction in Contemporary Percutaneous Coronary Intervention Trials.

Reference: JACC Cardiovasc Interv. 2017 Apr 10;10(7):658-666.

Limited usefulness of the modified Academic Research Consortium stent thrombosis definition for clinical trials.

Reference: JACC Cardiovasc Interv. 2011 Oct;4(10):1151; author reply 1151-2.

Autopsy validation study of the academic research consortium stent thrombosis definition.

Reference: JACC Cardiovasc Interv. 2011 May;4(5):554-9.

Identifying stent thrombosis, a critical appraisal of the academic research consortium (ARC) consensus definitions: a lighthouse and as a toe in the water.

Reference: EuroIntervention. 2008 Aug;4 Suppl C:C39-44.

Incidence of coronary stent thrombosis based on academic research consortium definitions.

Reference: Am J Cardiol. 2008 Sep 15;102(6):683-8.

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