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Bleeding Events

In response to the need to develop, disseminate, and ultimately adopt standardized bleeding end-point definitions for patients receiving antithrombotic therapy, the Bleeding Academic Research Consortium (BARC) convened in February 2010 at the US Food and Drug Administration (FDA) headquarters in White Oak, Maryland. Modeled after the 2006 Academic Research Consortium, which standardized key ischemic end-point definitions in studies aimed at evaluating coronary stents, the BARC effort brought together representatives from academic research organizations, the FDA, the National Institutes of Health, and pharmaceutical and cardiovascular device manufacturers and independent physician thought leaders in the field of cardiovascular disease to develop consensus bleeding definitions that would be useful for cardiovascular clinical trials. Application of these definitions is recommended for both clinical trials and registries.

Note: paragraph extracted from BARC, available through the link below.

ARC Publications

Bleeding Academic Research Consortium (BARC-1)

Standardized Bleeding Definitions for Cardiovascular Clinical Trials: A Consensus Report From the Bleeding Academic Research Consortium.

Reference: Circulation 2011; 123: 2736-2747

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Other relevant references

Assessing bleeding in acute coronary syndrome using the Bleeding Academic Research Consortium definition.

Reference: J Cardiovasc Med (Hagerstown). 2019 Dec;20(12):818-824.

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Validation of the Bleeding Academic Research Consortium Bleeding Definition: Towards a Standardized Bleeding Score.

Reference: J Am Coll Cardiol. 2016 May 10;67(18):2145-2147.

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Clinical utility of new bleeding criteria: a prospective study of evaluation for the Bleeding Academic Research Consortium definition of bleeding in patients undergoing percutaneous coronary intervention.

Reference: J Cardiol. 2015 Apr;65(4):324-9.

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Prospective validation of the Bleeding Academic Research Consortium classification in the all-comer PRODIGY trial.

Reference: Eur Heart J. 2014 Oct 1;35(37):2524-9.

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The prognostic value of BARC-defined bleeding complications in ST-segment elevation myocardial infarction: a comparison with the TIMI, GUSTO, and ISTH bleeding classifications.

Reference: J Am Coll Cardiol. 2014 May 13;63(18):1866-75.

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Impact of in-hospital bleeding according to the Bleeding Academic Research Consortium classification on the long-term adverse outcomes in patients undergoing percutaneous coronary intervention.

Reference: Catheter Cardiovasc Interv. 2015 Jan 1;85(1):63-71.

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Prognostic implications of bleeding measured by Bleeding Academic Research Consortium (BARC) categorisation in patients undergoing primary percutaneous coronary intervention

Reference: Heart. 2014 Jan;100(2):146-52.

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Letter by Mehran et al regarding article, "Bleeding academic research consortium consensus report: the food and drug administration perspective".

Reference: Circulation. 2012 Mar 13;125(10):e460.

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Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention

Reference: Circulation. 2012 Mar 20;125(11):1424-31.

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Bleeding Academic Research Consortium consensus report: the Food and Drug Administration perspective

Reference: Circulation. 2011 Jun 14;123(23):2664-5.

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Editorial: do we need another bleeding definition? What does the Bleeding Academic Research Consortium definition have to offer?

Reference: Curr Opin Cardiol. 2011 Jul;26(4):275-8.

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